https://www.ceesdekker.net Secrets

‘The next is nanopores, and that is our oldest line of investigate and which has now led to DNA sequencers according to nanopores. We pull person DNA strands through a nanopore and can then examine off the nucleotide sequence. Really a short while ago, we even managed to browse out one protein for The very first time utilizing This system. But this line of investigate is don't just about establishing equipment, and also about true biological concerns.

Our group scientific tests bacterial mobile division and it is aiming to constitute a ‘bottom up biology’ in synthetic cells that could autonomously divide. Our key fascination lies in cell division, chromatin construction, and spatial Manage.

, Groningen scientists present the outcomes of their initiatives for making labs extra sustainable and supply tips for other labs. 

Since 2000, Dekker has shifted the principle aim of his perform toward biophysics where he reports the Attributes of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of discipline was pushed by his fascination with the outstanding operating of Organic molecular buildings, along with with the extensive-time period perspective that a lot of exciting discoveries is often envisioned in this area.[5] Existing traces of exploration in his biophysics team are during the parts of:[six]

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Microbiology has only been around for any century, due to the fact we started to study micro-organisms far more seriously. I thought nanobiology was an proper phrase, due to the fact all molecular Organic related interactions take place at the nanoscale: a protein is a handful of nanometres in sizing, DNA is two nm thick.’

We use nanofabricated microfluidic structures to pattern spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement within the molecular and mobile stage. Our initiatives include things like the next:

Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation

‘You shouldn't just contemplate the issues of tomorrow, but will also consider the questions of the day after tomorrow’

Very amazing, but that cees dekker wasn’t definitely in which my desire lay. I desired to pioneer And that i experienced the feeling which was now not achievable, as the most intriguing essential insights had presently been uncovered. But my subject experienced developed many enjoyable new applications to measure specific molecules. I made a decision which i wanted to use this to biology, to take a look at it from the Bodily viewpoint.’

Screening pseudotopological and nontopological designs for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments

1999, very first measurement of your wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof to get a new Luttinger description of interacting electrons in nanotubes

2005, discovery on the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-vary conformational adjustments in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in the nanopore

The biophysicist from Delft – who continues to be Probably the most cited scientists in the Netherlands For some time – can take his accountability to contribute to the rationalization and popularisation of his get the job done with the border of physics and biology incredibly critically and regularly seems while in the media; if not to take a look at his get the job done, then about the relationship between science and his Christian religion.